Correlation between blood pressure stage and serum cardiovascular active peptide Salusin levels in pa-tients with essential hypertension / 心血管康复医学杂志

ABSTRACT

Objective:To explore correlation between stage cardiovascular active peptide salusin levels and class of essential hy-pertension (EH).Methods:A total of 145 EH patients were selected ,including 45 cases of hypertension stage 1 ,52 cases of stage 2 and 48 cases of stage 3- Another 50 healthy normotensive subjects undergoing physical examination simultaneously were enrolled as healthy control group .Levels of blood lipids ,serum salusin-α and salusin-β were measured and compared a-mong above groups .Results:Compared with healthy control group ,there was significant reduction in serum salusin-α level ,a-long with EH stage (1 ,2 ,3)rose ,there was significant reduction in serum salusin-α level [(2-40 ± 0-18)ng／ml vs.(1-17 ± 0-33) ng／ml vs.(0-82 ± 0-04)ng／ml vs.(0-60 ± 0-09)ng／ml , P＝0-001 all]in EH patients ;there was significant rise in serum sa-lusin-β level ,along with EH stage (1 ,2 ,3) rose ,there was significant rise in serum salusin-β level [(2-47 ± 0-28)ng／ml vs. (3-90 ± 0-26)ng／ml vs.(4-43 ± 0-09)ng／ml vs.(4-74 ± 0-10)ng／ml ,P＝0-001 all]in EH patients.Spearman correlation anal-ysis indicated that EH stage was significant inversely correlated with serum salusin-α level (r＝ －0-936 ,P＝0-001) ,and signif-icant positively correlated with serum salusin-β level (r＝0-526 , P＝0-001).Conclusion:Serum salusin-α and salusin-β possess certain predictive significance for hypertension stage ,which may provide new thinking for antihypertensive therapy .