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Therapeutic effect of amlodipine atorvastatin calcium tablet on hypertensive patients and its influence on blood pressure and blood lipids / 心血管康复医学杂志
Chinese Journal of cardiovascular Rehabilitation Medicine ; (6): 329-333, 2019.
Article in Chinese | WPRIM | ID: wpr-753123
ABSTRACT

Objective:

To explore therapeutic effect of amlodipine atorvastatin calcium tablet on hypertensive pa-tients .

Methods:

A total of 112 hypertensive patients treated in our hospital were randomly and equally divided into amlodipine group (received amlodipine 5mg/d) and amlodipine atorvastatin group (received amlodipine atorvastatin calcium tablet 15mg/d) ,both groups were treated for eight weeks .Therapeutic effect and incidence of adverse reac- tions ,blood pressure and blood lipids before and after treatment were compared between two groups .

Results:

Com-pared with before treatment ,there were significant reduction in levels of blood pressure and blood lipids (except sig-nificant rise in HDL-C level) in two groups after treatment , P<0-05 or <0-01 ;compared with amlodipine group , there was significant rise in total effective rate (62-5% vs.96-4%, P=0-001) ,and significant reduction in inci-dence rate of adverse reactions (28-5% vs.3-5%) , P= 0-003 ;significant reductions in levels of blood pressure [ (147-5 ± 10-1)/(90-7 ± 8-2) mmHg vs.(133-2 ± 9-4)/(86-9 ± 8-2) mmHg] ,total cholesterol [ (5-7 ± 1-3) mmol/L vs .(5-2 ± 0-8) mmol/L] ,triglyceride [(2-5 ± 1-2) mmol/L vs.(1-9 ± 0-5) mmol/L] and low density lip-oprotein cholesterol [ (4-1 ± 0-7) mmol/L vs.(3-1 ± 0-6) mmol/L] in amlodipine atorvastatin group , P<0-05 or<0-01-

Conclusion:

Amlodipine atorvastatin calcium tablet can significantly improve blood pressure and blood lipids with few adverse reactions in hypertensive patients ,which is worth extending .

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of cardiovascular Rehabilitation Medicine Year: 2019 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of cardiovascular Rehabilitation Medicine Year: 2019 Type: Article