Therapeutic effect of compound Danshen dripping pills combined atorvastatin on coronary heart disease complicated hyperlipidemia and its influence on serum TRAIL level / 心血管康复医学杂志

ABSTRACT

Objective:To explore therapeutic effect of compound Danshen dripping pills combined atorvastatin on cor-onary heart disease (CHD) complicated hyperlipidemia and its influence on serum level of tumor necrosis factor-re-lated apoptosis inducing ligand (TRAIL).Methods: A total of 109 CHD patients with hyperlipidemia treated in our department of cardiology were collected ,randomly divided into atorvastatin group (n＝57) and combined treatment group (n＝ 52 ,received atorvastatin combined compound Danshen dripping pills ) ,both groups were continuously treated for three months .Cardiac function ,levels of blood lipids ,serum tumor necrosis factor (TNF)-α ,TRAIL and quality of life (QOL ) were measured and compared between two groups before and after treatment .Results:Compared with before treatment ,there were significant improvements in cardiac function and blood lipid levels , and significant reductions in serum levels of TNF-α and TRAIL in two groups after treatment , P＝0-001 all ;com-pared with atorvastatin group after treatment ,there were significant rise in cardiac output [ (4-1 ± 0-8) L／min vs. (4-9 ± 0-6) L／min] ,cardiac index [ (3-9 ± 0-6) L·min-1 ·m-2 vs.(4-2 ± 0-7) L·min-1 ·m-2 ] ,LVEF [ (52-4 ± 1-6)% vs.(59-6 ± 1-5)%] ,serum HDL-C [ (1-5 ± 0-4) mmol／L vs.(1-9 ± 0-5) mmol／L] and QOL [ (6-2 ± 0-8) scores vs .(7-1 ± 1-1) scores] ,and significant reductions in LVEDd [ (5-4 ± 0-6) cm vs.(5-0 ± 0-7) cm] ,serum levels of TC [ (4-1 ± 0-7) mmol／L vs.(3-7 ± 0-9) mmol／L] ,TG [ (1-4 ± 0-6) mmol／L vs.(1-1 ± 0-5) mmol／L] , LDL-C [ (2-9 ± 0-8) mmol／L vs .(2-4 ± 0-8) mmol／L] ,TNF-α [ (52-1 ± 12-6) ng／L vs.(41-3 ± 14-2) ng／L] and TRAIL [ (44-7 ± 24-1) pg／ml vs.(34-1 ± 26-6) pg／ml] in combined treatment group , P＜0-05 or ＜ 0-01- Conclusion: Compound Danshen dripping pills combined atorvastatin can significantly improve heart function ,re-duce blood lipid levels and improve quality of life in CHD patients with hyperlipidemia .