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Predictive value of plasma BNP for prognosis in patients with chronic heart failure preserved ejection fraction/ / 心血管康复医学杂志
Chinese Journal of cardiovascular Rehabilitation Medicine ; (6): 410-414, 2019.
Article in Chinese | WPRIM | ID: wpr-753144
ABSTRACT
To observe predictive value of plasma brain natriuretic peptide (BNP) for prognosis in patients with chronic heart failure preserved left ventricular ejection fraction (HFpEF).

Methods:

A total of 122 CHF pa‐tients from 2014 to 2016 , according to LVEF , patients were divided into LVEF reduced HF (HFrEF ) group (LVEF≤ 40%, n= 41) , HF with medium LVEF (HFmEF ) group (40% < LVEF< 50%, n= 40 ) and HFpEF group (LVEF≥50%, n= 41).Clinical data , plasma BNP level etc .were measured and compared among three groups ;ROC was used to analyze cutoff point of plasma BNP predicting short‐term major adverse endpoint (SMAE) in CHF patients .

Results:

For LVEDd , HFpEF grou P< HFmEF group< HFrEF group , there existed significant difference between any two groups , P=0.001 all.Left atrial diameter (LAD) of HFpEF group and HFmEF group were significantly higher than that of HFrEF group , P<0.05 both .Compared with HFpEF group , there was sig‐nificant rise in plasma BNP level [(789.39 ± 455.62) pg/ml vs.(1143. 40 ± 567.99) pg/ml vs.(2341.51 ± 1029. 99) pg/ml] in HFmEF group and HFrEF group , and that of HFrEF group was significantly higher than that of HFmEF group , P<0. 01 all.Multifactor Logistic regression indicated that plasma BNP level was independent risk factor for SMAE events in HFmEF and HFrEF patients (OR=1.006 , 1.001 , P<0.05 both).ROC analysis indicated that AUC of plasma BNP predicting SMAE in CHF patients was 0.818 , cutoff point was 1415pg/ml , and sensitivity and specificity was 82. 6% and 72. 7% respectively .There was no significant difference in rehospitalization rate and mortality during hospitalization and within 12‐month follow‐up after discharge among three groups , P= 0.328.

Conclusion:

Plasma BNP possesses good predictive value for short‐term rehospitalization and death events in HFmEF and HFrEF patients , but it can′t predict endpoint events of HFpEF patients .

Full text: Available Index: WPRIM (Western Pacific) Type of study: Prognostic study / Risk factors Language: Chinese Journal: Chinese Journal of cardiovascular Rehabilitation Medicine Year: 2019 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Type of study: Prognostic study / Risk factors Language: Chinese Journal: Chinese Journal of cardiovascular Rehabilitation Medicine Year: 2019 Type: Article