The relationship among serum H‐FABP , Hcy levels and ventricular remodeling , prognosis in patients with CHF／ / 心血管康复医学杂志

ABSTRACT

To analyze the relationship among serum heart type fatty acid binding protein (HFABP) , ho‐mocysteine (Hcy) levels and ventricular remodeling , prognosis in patients with chronic heart fail (CHF).Methods:A total of 128 patients with CHF admitted to our hospital from May 2013 to Nov 2015 were enrolled .According to the New York Heart Association (NYHA) cardiac function grading , patients were divided into three groups grade II (n＝48) , grade III (n＝42) and grade IV (n＝38) , at the sane time 35 patients with heart function grade I as a control group .Cardiac examination was performed by echocardiography to obtain parameters related to left ventric‐ular remodeling .The levels fo serum H‐FABP and Hcy were measured on the next day of admission , and correlation analysis was performed .All patients were treated with targeted cardiac therapy and followed up for 24 months.The cardiac events were used as the end point of the study , indicating poor prognosis .The relationship among serum H‐FABP and Hcy levels and prognosis was analyzed .Results: Left ventricular end diastolic diameter (LVEDd ) [ (40.40 ± 4.41) mm vs .(42. 64 ± 3.22) mm vs.(45.20 ± 3. 41 ) mm vs.(46. 94 ± 4.22) mm] , left ventricular posterior wall thickness (LVPW) [ (8.45 ± 1.15) mm vs.(9. 04 ± 1. 21) mm vs.(10.05 ± 1.35) mm vs.(11. 94 ± 1.27) mm] , and interventricular septum thickness (IVS) [ (7. 01 ± 0.92) mm vs.(8.93 ± 1. 12) mm vs.(10. 09 ± 1.29) mm vs.(11. 93 ± 1. 32) mm] were significantly increased in patients with grade I , II , III , and IV , and left ventricular ejection fraction ( LVEF) [ (52.16 ± 4.02)% vs.(50. 32 ± 3.29)% vs .(48.16 ± 3. 32)% vs.(45.32 ± 2.29)%] decreased significantly ( P＜0. 05 or P＜0. 01) , and serum H‐FABP [ (3. 36 ± 0.71 ) ng／L vs.(4. 13 ± 1.13) ng／L vs .(5. 65 ± 1.42) ng／L vs.(6.49 ± 1. 69) ng／L] and Hcy [ (9. 46 ± 1.55) μmol／L vs.(14. 49 ± 2. 60) μmol／L vs.(17.71 ± 3. 61) μmol／L vs.(20. 26 ± 3. 37 ) μmol／L ] levels increased significantly ( P＜ 0.05 or P＜0.01).Pearson correlation analysis showed that serum H‐FABP and Hcy levels were positively correlated with LVEDd , IVS and LVPW ( r＝0.312～0. 392 , P＜0.05) , and negatively correlated with LVEF ( r＝ －0.453 ,－0.484 , P＜0.05).During 24 months of follow‐up , 56 patients (43. 75%) with CHF had a poor prognosis , com‐pared with the prognosis group , serum H‐FABPP [ (4. 74 ± 1.43) ng／L vs.(6.27 ± 1.28 ) ng／L ] and Hcy level [ (11.35 ± 2.03) μmol／L vs.(18.33 ± 3.46) μmol／L] in the poor prognosis group were significantly increased (P＝0.001 ).Conclusion: There is certain correlation between serum H‐FABP and Hcy levels and ventricular remodeling in patients with CHF , which plays an important role in the assessment of disease and prognosis .