Influence of recombinant human BNP combined Astragalus injection on heart function and serum levels of inflammatory factors in AMI patients with post‐PCI heart failure／ / 心血管康复医学杂志

ABSTRACT

To explore influence of recombinant human B type natriuretic peptide (rhBNP) combined As‐tragalus injection on heart function and serum levels of inflammatory factors in AMI patients with post‐percutaneous coronary intervention (PCI) heart failure .Methods: A total of 96 AMI patients with post‐PCI heart failure were randomly and equally divided into rhBNP group (received rhBNP based on routine treatment ) and combined treat‐ment group (received Astragalus injection based on rhBNP group ) , both groups were treated for 14d.Clinical thera‐peutic effect , heart function , serum levels of N terminal pro BNP (NT‐proBNP) , tumor necrosis factor (TNF)‐α , hsCRP , matrix metalloproteinase (MMP)‐9 and myeloperoxidase (MPO) before and after treatment , and inci‐dence of adverse reactions were observed in two groups .Results: After treatment , total effective rate of combined treatment group was significantly higher than that of rhBNP group (91.67% vs .72.92%, P＝0. 016).Compared with rhBNP group after treatment , there was significant rise in LVEF [ (44.26 ± 7.39)% vs.(49. 67 ± 7.46)%] , and significant reductions in LVEDV [ (129.27 ± 8.71) ml vs .(117.39 ± 7.59) ml] , LVESV [ (78.10 ± 6.22) ml vs.(66. 74 ± 5.96) ml] , serum levels of NT‐proBNP [ (968.43 ± 172.49 ) ng／L vs.(796. 30 ± 158. 24 ) ng／L ] , TNF‐α [(118. 67 ± 23.59) ng／L vs.(97.73 ± 18.48) ng／L] , hsCRP [(4. 19 ± 0. 85) mg／L vs.(3. 38 ± 0. 57) mg／L] , MMP‐9 [ (82.47 ± 14. 28) ng／ml vs .(60. 92 ± 11. 45) ng／ml] and MPO [ (497. 52 ± 64.32) mg／L vs.(452. 82 ± 60.57) mg／L] in combined treatment group , P＝0.001 all.There was no significant difference in incidence rate of adverse reactions between two groups , P＝0.584. Conclusion: RhBNP combined Astragalus injection can signifi‐ cantly improve heart function , relieve inflammatory reactions with safety in AMI patients with post‐CI heart fail‐ure , which is worth extending .