Epidemiology of Ciprofloxacin Resistance and Its Relationship to Extended-Spectrum beta-Lactamase Production in Proteus mirabilis Bacteremia
The Korean Journal of Internal Medicine
;
: 89-93, 2011.
Article
in English
| WPRIM
| ID: wpr-75322
ABSTRACT
BACKGROUND/AIMS:
We evaluated the clinical features of ciprofloxacin-resistant Proteus mirabilis bacteremia and risk factors for ciprofloxacin resistance.METHODS:
From October 2000 to July 2009, 37 patients with clinically significant P. mirabilis bacteremia were identified and data from patients with ciprofloxacin-resistant and ciprofloxacin-susceptible P. mirabilis bacteremia were compared.RESULTS:
The most common underlying diseases were neurologic disease (37.8%) and solid tumors (29.7%). The most common site of infection was the urinary tract (35.1%). Ten of the 37 patients (27.0%) were infected with ciprofloxacin-resistant isolates, and univariate analysis revealed a significant relationship between ciprofloxacin-resistant P. mirabilis bacteremia and neurologic disease, recent operation, L-tube insertion, percutaneous tube use, and extended-spectrum beta-lactamase (ESBL) production (all p < 0.05). ESBL was detected in six of 10 (60%) ciprofloxacin-resistant isolates, while only three of 27 (11%) ciprofloxacin-susceptible isolates produced ESBL (p = 0.005). In a logistic regression analysis, ESBL production remained a significant factor associated with ciprofloxacin resistance, after adjusting for other variables.CONCLUSIONS:
These data indicate a close association between ciprofloxacin resistance and ESBL-production in P. mirabilis bacteremia. This association is particularly troublesome because the therapeutic options for serious infections caused by ESBL-producing P. mirabilis are severely restricted.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Proteus Infections
/
Proteus mirabilis
/
Beta-Lactamases
/
Ciprofloxacin
/
Risk Factors
/
Bacteremia
/
Drug Resistance, Bacterial
/
Anti-Infective Agents
Type of study:
Etiology study
/
Prognostic study
/
Risk factors
/
Screening study
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
English
Journal:
The Korean Journal of Internal Medicine
Year:
2011
Type:
Article
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