Prostaglandin D2 and TH2 Inflammation in the Pathogenesis of Bronchial Asthma
The Korean Journal of Internal Medicine
;
: 8-18, 2011.
Article
in English
| WPRIM
| ID: wpr-75334
ABSTRACT
Prostaglandin D2 (PGD2) is a major prostanoid, produced mainly by mast cells, in allergic diseases, including bronchial asthma. PGD2-induced vasodilatation and increased permeability are well-known classical effects that may be involved in allergic inflammation. Recently, novel functions of PGD2 have been identified. To date, D prostanoid receptor (DP) and chemoattractant receptor homologous molecule expressed on TH2 cells (CRTH2) have been shown to be major PGD2-related receptors. These two receptors have pivotal roles mediating allergic diseases by regulating the functions of various cell types, such as TH2 cells, eosinophils, basophils, mast cells, dendritic cells, and epithelial cells. This review will focus on the current understanding of the roles of PGD2 and its metabolites in TH2 inflammation and the pathogenesis of bronchial asthma.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Asthma
/
Basophils
/
Receptors, Prostaglandin
/
Receptors, Immunologic
/
Prostaglandin D2
/
Th2 Cells
/
Eosinophils
/
Mast Cells
Type of study:
Etiology study
Limits:
Humans
Language:
English
Journal:
The Korean Journal of Internal Medicine
Year:
2011
Type:
Article
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