Changes of Serum PCT, PA, TF, AMY Levels and Prognosis in ICU Patients with Severe Acute Pancreatitis by Nutritional Support of Early Enteral Nutrition Suspension Combined with Somatostatin / 医学研究杂志

ABSTRACT

Objective To investigate the effect of early enteral nutrition suspension nutritional support combined with somatostatin on serum procalcitonin (PCT), prealbumin (PA), transferrin (TF) and amylase (AMY) in ICU patients with severe acute pancreatitis. Methods From July 2014-November 2016, 66 cases of ICU severe pancreatitis in Beijing Tongren Hospital were divided into control group and treatment group according to treatment plan, 33 cases each group. The control group was given early parenteral nutrition support + somatostatin treatment, The treatment group was given early enteral nutrition suspension nutrition support + somatostatin treatment. Complications of the tw groups were compared, prognostic score (APACHEII, SOFA and modified Marshall scores), serum PCT, PA, TF, AMY levels and serum-related inflammatory factors [interleukin-6 (IL-6), interleukin-10 (IL-10), tumor necrosis factor - α (TNF-α) ]before and after treatment were compared. Results There was no significant difference in APACHEII, SOFA and modified Marshall scores between the two groups before treatment (P ＞ 0. 05). Compared with the control group after treatment, the APACHEII, SOFA and modified Marshall scores of the treatment group were lower than those of the control group (P ＜ 0. 05). There was no significant difference in serum PCT, PA, TF and AMY between the two groups before treatment (P ＞ 0. 05). Compared with the control group after treatment, the levels of serum PCT and AMY in the treatment group were lower than those in the control group, and the levels of serum PA and TF were higher (P ＜ 0. 05). There was no significant difference in serum TNF-α, IL-6 and IL-10 levels between the two groups before treatment (P ＞ 0. 05). Compared with the control group after treatment, the levels of serum TNF-α and IL-6 in the treatment group were lower than those in the control group, and the serum IL-10 level was higher (P ＜ 0. 05). The incidence of complications in the treatment group was 15. 15％ (5 /33) lower than that in the control group (42. 42％, 14 /33), the difference was statisti- cally significant (P ＜ 0. 05). Conclusion Early stage enteral nutrition suspension nutrition support combined with somatostatin in the treatment of ICU severe pancreatitis patients can effectively improve serum levels of PA, TF and IL-10, reduce PCT, AMY, TNF-α, IL-6 levels, improve the prognosis, and its security is high.