Advances in fluorosis-induced nervous system injury and antagonistic protection / 中华地方病学杂志

ABSTRACT

The damage of nervous system caused by fluorosis has been paid more and more attention. Fluorosis can lead to memory loss, mental retardation and cognitive deficits in children. Advance in the understanding of the mechanism of fluorosis induced nervous system damage will be summarized here from several aspects, including oxidative stress, signal transduction and neurotransmitters and receptors. Oxidative stress is the central link in the mechanism of fluorotoxic nerve damage. Studies have suggested that in addition to some antioxidant drugs and preparations, black garlic, which is a food, has many biological effects such as antioxidants. It suggested that black garlic may have protective effects on fluorosis nerve injury through analyzing the antioxidant property and neuroprotective effects of black garlic, further studies are needed to address the effect and the underlying mechanism of black garlic.