Retrospective analysis of clinical features of chronic obstructive pulmonary disease complicated with pulmonary thromboembolism / 中国基层医药

ABSTRACT

Objective To analyze the clinical features of patients with chronic obstructive pulmonary disease (COPD) complicated with pulmonary thromboembolism (PTE).Methods The clinical data of 21 patients with COPD and PTE and 26 patients with acute exacerbation of COPD(AECOPD) from June 2015 to March 2018 in Taiyuan Central Hospital were retrospectively analyzed.The SSPS 22.0 statistical software was used to analyze the clinical data.General data,blood gas analysis results,lung function,hemoglobin,coagulation parameters,combined disease were analyzed.Results There were no statistically significant differences in age,gender and lung function grading between the COPD complicated with PTE group and AECOPD group (all P ＞ 0.05).The incidence rates of chest pain(8 cases,38.1％) and syncope(2 cases,10.5％) in the COPD complicated with PTE group were higher than those in the AECOPD group [chest pain (3 cases,11.5 ％),syncope (1 case,3.8 ％)] (x2 =7.645,9.413,all P ＜0.05).There was no statistically significant difference in carbon dioxide partial pressure (PaCO2)retention between the two groups(P＞0.05).The blood oxygen partial pressure(PaO2) of the COPD complicated with PTE group was (62.86 ± 15.10)mmHg,which was lower than that of the AECOPD group [(74.83 ± 17.59)mmHg] (t =4.642,P ＜ 0.05).The hemoglobin,activated partial thromboplastin time (APTT),fibrinogen (FIB),D-dimer levels in the COPD complicated with PTE group were (146.78 ± 21.40) g/L,(35.62 ± 5.93) s,(4.34 ± 1.18) g/L,(5.02 ± 3.63)mg/L,respectively,which were higher than those in the AECOPD group [(137.45 ± 15.15)g/L,(29.38 ±3.16) s,(3.62 ± 1.08) g/L,(0.92 ±0.42) mg/L] (t =4.375,4.654,3.869,18.653,all P ＜0.05).There were no statistically significant differences in the proportion of comorbidities such as diabetes,hypertension,hyperlipidemia and lower extremity (all P ＞ 0.05).Conclusion COPD patients complicated with PTE have the following characteristicselderly and male patients accounted for a high proportion,chest pain and syncope symptoms occurred in a high proportion,severe hypoxia,hemoglobin and D-dimer increased significantly.