Effect of linezolid on inflammatory factors and T lymphocyte levels in patients with severe tuberculosis / 中国基层医药

ABSTRACT

Objective To observe the effects of linezolid on the levels of inflammatory factors and T lymphocytes in patients with severe tuberculosis.Methods Sixty patients with severe tuberculosis treated in Jinhua Guangfu Hospital from April 2016 to November 2017 were selected and divided into control group(n =30) and observation group(n =30) according to different treatment options.The control group was treated with personalized anti-tuberculosis regimen.The observation group was treated with linezolid on the basis of the control group,and both two groups were treated for 9 months.The changes of interleukin-1 (IL-1),tumor necrosis factor alpha (TNF-α),IL-6,IL-10 and CD3+,CD4+,CD8+ and CD4+/CD8+ were observed before and after treatment.The incidence of liver injury,thrombocytopenia,myelosuppression,nausea and vomiting,diarrhea were observed.Results Before treatment,there were no statistically significant differences in IL-1,TNF-α,IL-6,IL-10,CD4+,CD8+,CD8+,CD4+/CD8+ between the two groups(all P＞0.05).At 9 months after treatment,the levels of IL-1,TNF-α,IL-6 and IL-10 in the control group were (10.94 ± 1.31) ng/L,(3.03 ± 0.49) ng/L,(183.43 ± 13.24) ng/L,(134.93 ± 34.51) ng/L,respectively,which in the observation group were (6.89 ± 1.29) ng/L,(2.49 ± 0.45) ng/L,(129.48 ± 10.74) ng/L,(189.35 ± 43.27)ng/L,respectively,the differences between the two groups were statistically significant(t =12.195,11.214,8.414,11.291,all P ＜ 0.05).The CD3+,CD4+,CD8+,CD4+/CD8+ in the control group were (47.61 ± 7.16) ％,(15.49 ± 6.64) ％,(20.58 ± 5.61) ％,(0.79 ± 0.19),respectively,which in the observation group were (65.46 ± 8.31) ％,(30.23 ± 7.85) ％,(34.59 ± 7.41) ％,(0.87 ± 0.24),respectively,the differences between the two groups were statistically significant (t =10.497,7.865,12.128,10.291,all P ＜ 0.05).There were no statistically significant differences in the incidence of liver function impairment,thrombocytopenia,myelosuppression,nausea and vomiting,and diarrhea between the two groups(all P ＞ 0.05).Conclusion Linezolid in the treatment of severe tuberculosis can reduce the level of inflammatory factors,improve the cellular immune level of patients,and has a lower incidence of adverse effects.