Effect of Shuxuening combined with edaravone on neurological function,serum VEGF and serum sVCAM-1 in patients with cerebral infarction / 中国基层医药

ABSTRACT

To investigate the effects of Shuxuening injection combined with edaravone on neuro -logical function,serum vascular endothelial growth factor ( VEGF) and soluble vascular cell adhesion molecule -1 (sVCAM-1) in patients with cerebral infarction.Methods A total of 112 patients with cerebral infarction admitted to Zhejiang Provincial Armed Police Hospital from August 2016 to August 2018 were enrolled in the study.They were divided into observation group and control group according to the digital table ,with 56 patients in each group.The two groups were given routine symptomatic treatment.On the basis of this, the control group was given edaravone treatment,and the observation group was given Shuxuening injection combined with edaravone .The changes of NIHSS, GCS score,serum NSE,NGF,NTF,VEGF and sVCAM -1 levels before and after treatment were compared between the two groups,and the clinical efficacy was compared.Results After treatment,the effective rate of the observation group was 92.86%(52／56),which was higher than that of the control group 73.21%(41／56),the difference was statistically significant (χ2 ＝7.669,P＜0.05).After treatment,the NIHSS score,NSE,sVCAM-1 of the two groups were decreased,which of the observation group were lower than those of the control group [(3.27 ±1.16)points vs. (6.32 ±2.12)points,(13.15 ±1.14)μg／L vs.(17.64 ±1.89)μg／L,(648.56 ±134.67)ng／mL vs.(1 078.36 ± 131.23 ) ng／mL], while the GCS score, NGF, NTF, VEGF levels of the two groups were elevated , which of the observation group were higher than those of the control group [(13.64 ±3.86) points vs.(11.89 ±3.41) points, (76.13 ±8.72) μg／L vs.( 68.24 ±7.25 ) μg／L, ( 5.14 ±0.36 ) μg／L vs.(3.74 ±0.29) μg／L, (831.51 ± 91.67)ng／L vs.(752.83 ±91.24) ng／L],the differences were statistically significant (t＝9.414,2.543,15.223, 5.205,22.663,4.552,15.672,all P ＜0.05).Conclusion Shuxuening injection combined with edaravone can improve the curative effect of patients with cerebral infarction ,improve neurological function,effectively improve serum VEGF level and decrease sVCAM -1 level.It is worthy of clinical application.