Association Study between Schizophrenia and Monocyte Chemoattractant Protein-1(MCP-1) Gene Polymorphism / 신경정신의학
Journal of Korean Neuropsychiatric Association
;
: 454-460, 2003.
Article
in Korean
| WPRIM
| ID: wpr-75380
ABSTRACT
OBJECTIVES:
This study was aimed at comparing the Monocyte Chemoattractant Protein-1 (MCP-1) gene polymorphic variants of schizophrenics with those of normal controls, and to investigate its contribution to the development of schizophrenia.METHODS:
One hundred and thirty five schizophrenics in accordance with DSM-IV criteria and one hundred and fourteen healthy individuals participated in this study. DNA was extracted from peripheral blood using proteinase K, and the MCP-1 gene promoter region was amplified by polymerase chain reaction (PCR). Gene typing was analyzed by restriction fragment length polymorphism (RFLP) using restriction enzyme PvuII.RESULTS:
Distribution of the genotypes and alleles of MCP-1 gene in the patient group was not significantly different from that of the control group (p=0.145 and p=0.122, respectively). There was difference in the frequencies of genotypes between positive and negative subgroup (p=0.035), but no difference in frequencies of alleles between the two subgroups (p=0.078). There was no difference in scores of PANSS general, positive and negative subscale, the age of onset, the presence or absence of family history between patients with or without -2518G allele (p=0.979, p=0.378, p=0.056, p=0.256 and p=0.301, respectively).CONCLUSION:
We suggest that the polymorphism in the MCP-1 promotor gene may be the possible marker for subgouping of negative type schizophrenia.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Schizophrenia
/
Polymorphism, Restriction Fragment Length
/
DNA
/
Monocytes
/
Polymerase Chain Reaction
/
Promoter Regions, Genetic
/
Age of Onset
/
Chemokine CCL2
/
Endopeptidase K
/
Diagnostic and Statistical Manual of Mental Disorders
Limits:
Humans
Language:
Korean
Journal:
Journal of Korean Neuropsychiatric Association
Year:
2003
Type:
Article
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