Application effect of metoprolol in the treatment of atrial fibrillation complicated with chronic heart failure / 中国基层医药

ABSTRACT

Objective To investigate the application effect of metoprolol in the treatment of atrial fibrillation complicated with chronic heart failure (CHF).Methods From February 2015 to February 2019,398 elderly patients with atrial fibrillation and CHF in Wangjiangshan Branch of the People＇s Hospital of Zhejiang Province were selected in the study.The patients were divided into two groups according to the digital table ,with 199 case in each group.The control group was treated with rest ,digitalis inhalation,diuretics,angiotensin converting enzyme inhibitors ,nitrate and enteric－coated aspirin.The observation group was treated with metoprolol on this basis.The effective rate of treatment, heart rate changes before and after treatment , left ventricular ejection fraction and 6 －minute walking distance in the two groups were observed and analyzed.Results The effective rate of the observation group was 88.94%(177／199),which was significantly higher than 71.86%(143／199) in the control group,the difference was statistically significant (χ2 ＝18.433,P＝0.000).The highest heart rate,the lowest heart rate and the resting heart rate in the observation group after treatment were significantly better than those in the control group [( 115.12 ± 0.35)times／min vs.(122.12 ±16.22) times／min,(90.21 ±18.12) times／min vs.(94.12 ±11.11) times／min, (97.00 ±9.64)times／min vs.(102.03 ±11.20)times／min],the differences were statistically significant (t＝4.246, 4.783,4.662,all P＜0.05).The LVEF and 6 －minute walking distance of the observation group after treatment were significantly better than those of the control group [( 45.0 ±2.0 )% vs.( 41.0 ±3.0 )%, ( 340.09 ± 31.45)m vs.(302.43 ±29.45)m],the differences were statistically significant ( t＝4.246,7.662,all P＜0.05). Conclusion Digitalis combined with metoprolol can effectively control the heart rate of atrial fibrillation combined with CHF,improve ventricular function and increase cardiac endurance.The combined therapy is worthy of promoting in this disease.