Research progress on the relationship between complement system and diabetic microangiopathy / 中国医师杂志

ABSTRACT

Diabetic microangiopathy is an vital reason of disabling and death in patients with diabetes.Long-term hyperglycemia and insulin resistance in type 2 diabetes mellitus can be involved in the formation of microangiopathy by aggravating mitochondrial damage,inflammation,and protein kinase C/glycosylation end product pathways.Besides,in recent years,several studies have shown that the activation of complement system plays an important role in the progression of diabetic vascular disease (including diabetic microvascular and macrovascular disease).This review is about to discuss the role and mechanism of the complement system in the development of diabetes and its microandioathy.