Aberrant myeloid antigen co-expression is correlated with high percentages of CD34-positive cells among blasts of acute lymphoblastic leukemia patients: an Indian tertiary care center perspective
Blood Research
;
: 241-245, 2014.
Article
in English
| WPRIM
| ID: wpr-75437
ABSTRACT
BACKGROUND:
Aberrant myeloid antigen (MA) co-expression and high expression of CD34 antigen on the blasts of acute lymphoblastic leukemia (ALL) patients are independently reported to have a role in pathogenesis and prognosis. This study was conducted to determine whether these two parameters are related.METHODS:
A total of 204 cases of ALL were included in an analysis of blast immunophenotypic data. CD34 expression was categorized as low when less than 50% of blasts were CD34-positive (CD34low) and as high when 50% or more were CD34-positive (CD34high).RESULTS:
Of 204 cases of ALL, 163 and 41 were of B-cell origin (B-ALL) and T-cell origin (T-ALL), respectively. Of all cases, 132 (64.7%) showed co-expression of MA and among these, 101 (76.51%) were CD34high, while the remaining 31 (23.48%) were CD34low. Of 72 cases without MA co-expression, 25 (34.72%) were CD34high and 47 (67.25%) were CD34low. Furthermore, of 163 cases of B-ALL, 111 showed co-expression of MA and 84 of these were CD34high. Of 52 cases of B-ALL without MA expression, 22 were CD34high. Among 41 cases of T-ALL, 21 co-expressed MA, 17 of which were CD34high. Moreover, all 20 cases of T-ALL without co-expression of MA were CD34low. These differences were statistically significant.CONCLUSION:
We observed a strong correlation between aberrant MA expression and CD34high expression on the blasts of ALL. We hypothesize that these different patient subsets may represent unique prognostic characteristics.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
B-Lymphocytes
/
T-Lymphocytes
/
Immunophenotyping
/
Antigens, CD34
/
Precursor Cell Lymphoblastic Leukemia-Lymphoma
/
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
/
Tertiary Care Centers
/
Flow Cytometry
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Blood Research
Year:
2014
Type:
Article
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