Clinical observation of Chaihu Qingdan decoction in treating acute severe cholangitis after endoscopic biliary drainage / 中国中西医结合急救杂志

ABSTRACT

Objective To observe the clinical effect of using Chaihu Qingdan decoction in the treatment of acute severe cholangitis (ACST) after endoscopic biliary drainage (ENBD). Methods One hundred and thirty two patients with ACST with ENBD admitted to Dongli District Hospital of Tianjin from October 2016 to October 2017, they were divided into a control group (42 cases) and a Chaihu Qingdan decoction group (90 cases) according to whether the patients accepted traditional Chinese medicine (TCM) treatment or not. The patients in the control group and the Chaihu Qingdan decoction group (combined group) were all treated with ENBD; the control group received routine anti-inflammatory treatment; the combined group, on the basis of conventional anti-inflammatory treatment, additionally was treated with Chaihu Qingdan decoction (composition bupleurum chinense 18 g, capillary artemisia 30 g, astragalus root 20 g, radix paeoniae rubra 20 g, radix scutellariae 15 g, radix scutellariae 15 g, polygoni 15 g, rhododendron bungeanum 30 g, red cane 30 g, forsythia 20 g, bergamot15 g), 1 dose per day, 2 times daily, 10 days constituting a therapeutic course. After treatment, the difference of operation success rate, abdominal pain relief time, postoperative body temperature return to normal time, liver function, the incidence of postoperative complications, hospitalization time were observed. Results The success rate of operation in the combined group was higher than that in the control group [97.78% (88/90) vs. 95.24% (40/42)], but the difference was not statistically significant (P > 0.05); the relief time of abdominal pain in the combined group was significantly shorter than that of the control group (days 6.1±1.1 vs. 7.4±1.5, P < 0.05), and the postoperative body temperature return to normal time in combined group was obviously shorter than that in the control group (days 2.1±0.4 vs. 2.2±0.6, P > 0.05). With the prolongation of treatment, the levels of body temperature, white blood cell count (WBC), direct bilirubin (DBil), alanine aminotransferase (ALT) and aspartate transaminase (AST) were decreased gradually in both groups, reaching the lowest levels on 10 days after treatment, and the above indexes in the combined group were significantly lower than those in the control group [body temperature (℃)36.44±0.24 vs. 37.04±0.39, WBC (×109/L) 7.03±1.23 vs. 8.92±2.11, DBil (μmol/L) 12.03±4.53 vs. 20.32±6.12, ALT (U/L) 31.23±4.23 vs. 68.92±6.19, AST (U/L) 34.03±11.23 vs. 78.92±22.19, all P < 0.05]; after treatment, the total bilirubin (TBil) in both groups was lower than that before treatment, and the combined group was significantly lower than that in the control group after treatment (μmol/L 61.59±11.64 vs. 82.33±12.05, P < 0.05); the incidence of complications in the combined group was significantly lower than that in the control group [3.33% (3/90) vs. 28.57% (12/42), P < 0.05], and the hospitalization time was shorter in the combined group than that in the control group (days11.4±2.2 vs. 18.2±3.4, P < 0.05). Conclusion For patients with severe biliary tract inflammation, ENBD combined with Chaihu Qingdan decoction can reduce postoperative complications, reduce abdominal pain relief time, and accelerate liver function recovery.