Advances in relationship between Na+-Ca2+ exchanger protein and acute kidney injury / 中国中西医结合急救杂志
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
; (6): 251-253, 2019.
Article
in Zh
| WPRIM
| ID: wpr-754548
Responsible library:
WPRO
ABSTRACT
Acute kidney injury (AKI) is a clinical syndrome characterized by a rapid decline of renal function in a short period of time. In recent years, the incidence of AKI has been increasing gradually. Once the AKI occurs in a patient whose mortality in hospital may be increased significantly, the length of stay in hospital will be prolonged and the hospitalization costs increased in a short term, the long-term consequences include AKI recurrence, development into chronic kidney disease (CKD) or end-stage kidney disease (ESRD), cardiovascular events and death, etc. Ischemia/reperfusion (I/R) injury and contrast agents are common causes of AKI. The nephropathy induced by I/R and contrast agent is associated with intracellular calcium overload caused by Na+-Ca2+ exchanger (NCX). In this article, a systematic review of the relationship between NCX and AKI was conducted, aiming to provide a reference for further recognizing the prevention, treatment and prognosis of AKI.
Full text:
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Index:
WPRIM
Language:
Zh
Journal:
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
Year:
2019
Type:
Article