Observation on curative effect of Qingrelishi prescription for treatment of rotavirus enteritis in children / 中国中西医结合急救杂志

ABSTRACT

Objective To investigate the clinical effect of Qingrelishi prescription in the treatment of infantile rotavirus enteritis (RE). Methods One hundred and twenty children with RE admitted to the Department of Intestinal Outpatient of Tianjin Children's Hospital from October to November 2018 were enrolled, and they were divided into a Qingrelishi prescription group and a western medicine treatment control group, 60 cases in each group. Qingrelishi prescription addition and/or subtraction was given to the Qingrelishi prescription group (composition of the prescription pueraria lobata, radix pseudostellariae, poria cocos, fried atractylodes macrocephala, each 6 g, scutellaria baicalensis, coptis chinensis, amomum villosum, argastaches leaves, roasted licorice, each 3 g), 1 dose a day, orally taken 1/2 dose twice a day, in thermogravimetric patients, plaster and rhizoma phragmititis were added, in cases with dampness, rhizoma alismatis and rhizoma atractylodis were added, and in patients with vomiting, bamboo shavings and pinellia were added; the western medicine treatment control group was given Montmorillonite powder. After 7 days of treatment, the clinical symptoms, changes of laboratory indexes and clinical efficacy were observed in both groups. Results After treatment, the number of children with stool soft, cases with fecal times less than 3 times per day and cases with reduction of fecal times ≥ 50% in Qingrelishi prescription group were obviously more than those in the western medicine treatment control group (fecal property soft 25 cases vs. 21 cases, fecal times less than 3 times per day 28 cases vs. 22 cases, cases with reduction of fecal times ≥ 50% 48 cases vs. 41 cases, all P < 0.05). The number of children with laboratory examination index of rotavirus antigen (RV-Ag) transformed into negative, the case number with pH value normal shown by blood gas analysis, cases with residual alkali (BE) normal and cases with urinary ketone body transformed into negative in the Qingrelishi prescription group were significantly higher than those in western medicine treatment control group (RV-Ag transformed into negative cases 49 cases vs. 42 cases, pH value normal cases48 cases vs. 42 cases, BE normal cases 51 cases vs. 43 cases, urinary ketone body transformed into negative cases52 cases vs. 44 cases, all P < 0.05). The total effective rate of Qingrelishi prescription group was significantly higher than that of the western medicine treatment control group [80.0% (48/60) vs. 68.33% (41/60)], the difference was statistically significantly (P < 0.05). Conclusion Qingrelishi prescription can significantly improve the clinical symptoms and laboratory examination indicators of children with RE, increase the total clinical efficacy, and its therapeutic effect is definite.