Associations of neutrophil to albumin ratio with acute adverse events and survival in patients with pathological stage Ⅱ/Ⅲ rectal cancer receiving adjuvant chemoradiotherapy / 中华放射医学与防护杂志

ABSTRACT

Objective To evaluate whether any association exists between peripheral blood cell-based inflammatory biomarkers obtained before adjuvant chemoradiotherapy and adverse events ( AEs) and survival of patients with pathological stage Ⅱ/Ⅲ rectal cancer treated by adjuvant chemoradiotherapy. Methods A total of 109 rectal cancer patients were included. The prognostic abilities of neutrophil to lymphocyte ratio ( NLR) , platelet to lymphocyte ratio ( PLR) , lymphocyte to monocyte ratio ( LMR) and neutrophil to albumin ratio ( NAR ) for overall survival ( OS ) were calculated by the receiver operating characteristic ( ROC) curves. Results NAR was associated with the occurrence of grade ≥2 leukopenia (OR=4. 442, 95％ CI1. 216-16. 221, P<0. 05). The 5-year OS rates of patients with NAR ≥ 0. 055 and patients with NAR<0. 055 were 68. 2％ and 83. 9％, respectively ( P>0. 05) . The 5-year disease-free survival ( DFS) rates of patients with NAR ≥ 0. 055 and patients with NAR<0. 055 were 59. 1％ and 76. 8％, respectively (χ2 =3. 887, P<0. 05 ) . Multivariate analysis by Cox proportional-hazards model showed that NAR was significantly associated with OS (HR=3. 035, 95％ CI1. 021-9. 019, P<0. 05). Conclusions These results suggest that NAR obtained before adjuvant chemoradiotherapy might serve as an independent biomarker for predicting AEs and prognosis in rectal cancer treated with adjuvant chemoradiotherapy.