Research progress on radiotherapy for brain metastasis from non-small-cell lung cancer with ALK rearrangement / 中华放射肿瘤学杂志

ABSTRACT

Brain metastasis is common in non-small-cell lung cancer (NSCLC) with driver gene mutations.At present,brain radiotherapy combined with tyrosine kinase inhibitor (TKI) is a hot topic.Anaplastic lymphoma kinase (ALK) gene rearrangement is one of the common driver mutations in NSCLC.However,the treatment of brain metastasis from NSCLC with ALK gene rearrangement has been rarely investigated.The prognosis of these patients,the role of brain radiotherapy and the proper comb ination of radiotherapy with ALK-TKI are worthy of further exploration.