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Disrupted network topology in patients with idiopathic rapid eye movement sleep behavior disorder / 中华核医学与分子影像杂志
Chinese Journal of Nuclear Medicine and Molecular Imaging ; (6): 325-330, 2019.
Article in Chinese | WPRIM | ID: wpr-755268
ABSTRACT
Objective To explore the topological abnormality of brain metabolic network in patients with idiopathic rapid eye movement sleep behavior disorder (iRBD) and compare it with the topology of brain metabolic network in patients with Parkinson's disease (PD).Methods The 18F-fluorodeoxyglucose (FDG) PET brain images of 19 patients with iRBD diagnosed with polysomnography (PSG) (iRBD group;15 males,4 females,average age64.9 years),19 patients with PD (PD group;12 males,7 females,average age62.2 years) and 19 gender and age-matched healthy controls (HC group;15 males,4 females,average age63.1 years) in Huashan Hospital from September 2014 to June 2015 were retrospectively analyzed.According to the complex brain network method based on graph theory,the brain metabolic networks of each group was constructed and the network parameters (clustering coefficient,characteristic path length,local efficiency,global efficiency and small-world property,etc) were evaluated quantitatively.The 500 times non-parametric permutation test was used to determine the differences in network parameters between groups.Results The brain metabolic networks of iRBD group and PD group both had abnormal topological structure,which showed that the characteristic path length (for example,when sparsity =34%,HC vs iRBD vs PD groups1.517 vs 1.552 vs 1.561) and local efficiency (for example,when sparsity=30%,HC vs iRBD vs PD groups0.802 vs 0.824 vs 0.831) were significantly increased (both P<0.05),the global efficiency (for example,when sparsity =36%,HC vs iRBD vs PD groups0.672 vs 0.658 vs 0.656) was significantly decreased (P<0.05).The topology was more aggravated in PD group compared with that in iRBD group.Conclusion The graph-based complex brain network analysis can reveal the abnormal topological structure of the brain metabolic network in which iRBD progresses to PD.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Nuclear Medicine and Molecular Imaging Year: 2019 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Nuclear Medicine and Molecular Imaging Year: 2019 Type: Article