Metabolic patterns of 11C-CFT and 18F-FDG PET/CT imaging in tremor and non-tremor Parkinson's / 中华核医学与分子影像杂志

ABSTRACT

Objective To investigate the metabolic patterns of 11C-2-beta-carbomethoxy-3-beta-(4-fluorophenyl)tropane (CFF) and 18F-fluorodeoxyglucose (FDG) PET/CT imaging in patients with tremor and non-tremor Parkinson's disease (PD).Methods From March 2018 to March 2019,28 PD patients (19 tremor patients14 males and 5 females,age(59.9±11.4) years;9 non-tremor patients3 males and 6 females,age(62.6±9.0) years) were enrolled.For the two groups,the 11C-CFT uptake values in caudate nucleus,anterior putamen and posterior putamen as well as 18F-FDG uptake values in all brain regions were calculated by regions of interest (ROI) method.Two-sample t test or Mann-Whitney u test were used to analyze the data.Results Caudate nucleus 11C-CFT uptake in PD patients with tremor was higher than that without tremor (3.03±0.51 vs 2.60±0.62;t =2.687,P＜0.05).Yet thalamus glucose uptake of non-tremor PD patients showed more active than tremor patients (1.14±0.05 vs 1.10±0.03;t =3.449,P＜0.01).Sorted by modified Hoehn-Yahr stage,tremor patients in advanced stage (stage≥2.5) were characterized by glucose uptake increase in the putamen and cerebellum compared with non-tremor advanced group (1.27±0.04 vs 1.21±0.05,0.94±0.04 vs 0.86±0.08;t values2.695 and 2.492,both P＜0.05).Metabolic decrease in the premotor areas was observed in tremor patients in advanced stage compared with early stage (1.07±0.02vs 1.10±0.03;t=2.053,P＜0.05).Conclusion 11C-CFT and 18F-FDG PET/CT imaging can indicate different metabolic patterns between tremor and non-tremor PD,thus providing information for clinical practice and differential diagnosis.