Relationships of serum level of retinol binding protein and adiponectin with renal injury in elderly patients with diabetic nephropathy / 中华老年医学杂志

ABSTRACT

Objective To investigate the relationships of serum level of retinol binding protein (RBP)and adiponectin(APN)with renal injury in elderly patients with diabetic nephropathy(DN).Methods A total of 50 patients with DN in our hospital from June 2016 to June 2018 were recruited in the retrospective study.According to the level of 24-hour urinary albumin excretion rate(UAER),the patients were divided into the low-level group(30-300 mg/d,n=30,)and the medium-level group(＞300 mg/d,n=20,).During the same period,50 patients with simple diabetes mellitus (DM)and 50 healthy persons were recruited as the DM group and the control group.Serum RBP and APN levels were determined in all groups.The relationships of APN and RBP level with 24-h UAER were analyzed by Pearson correlation analysis.Results Serum APN level(mg/L)was lower in DN(4.6± 0.9)patients than in DM(14.2±1.2)and in control groups(14.6±1.2) (P＜0.01).The serum levels of RBP(mg/L) was higher in DN patients(98.1 ± 10.2) than in DM (38.3 ± 3.5) and in control groups (37.1±3.2)(P＜0.05).The 24-h UAER was higher in DN patients(300.1±30.2)than in DM(13.1 ± 1.2) and in control groups(12.3 ± 1.5) (P ＜ 0.05).There was no significant difference in levels of serum RBP and APN and 24-hour UAER between the DM and control groups(P ＞ 0.05).Pearson correlation analysis showed that serum APN level was negatively correlated with 24-h UAER,and serum RBP level was positively correlated with 24-h UAER(r =-0.723 and 0.711,P＜0.01).Serum APN level was lower and serum RBP level was higher in medium-level group than in low-level group [(3.1±0.2) mg/L vs.(5.2±0.5) mg/L,(102.3±10.6) mg/L vs.(75.6±7.2) mg/L,t =21.829 and 10.661,respectively,all P＜0.01].Conclusions Serum RBP is positively related to,and APN level is negatively related to the occurrence and development of DN in elderly patients.Serum RBP and APN can be used as important indicators for evaluating renal injury in elderly patients.