Changes in Antibody Titers of Measles, Mumps, Rubella, and Hepatitis B Virus AftEr Bone Marrow Transplantation in Korea: A Preliminary Report / 감염
Korean Journal of Infectious Diseases
;
: 558-563, 1998.
Article
in Korean
| WPRIM
| ID: wpr-75554
ABSTRACT
BACKGROUND:
Bone marrow transplantation (BMT) has become a significant treatment modality for hematopoietic and solid organ malignancy. Recipients of BMTs lose immunity to measles-mumps-rubella (MMR) and hepatitis B infections which are preventable with vaccination. There is no consensus regarding a vaccination schedule after BMT and time of vaccination is variable according to each institution. We analyzed sequential changes in antibody titers of MMR and hepatitis B during the first year after BMT in an attempt to identify the time, dose, and needs for revaccination.METHODS:
Total 20 patients with hematologic malignancies were studied. Serum levels of IgG antibodies of MMR and hepatitis B virus (HBV) were determined every three months post-BMT by enzyme immunoassay (EIA), chemical luminescence immunoassay (CLIA) and immunofluorescence assay (IFA).RESULTS:
IgG antibody levels of measles, rubella, HBV were 1746, 80 85 IU/mL, 214 343 IU/L before BMT, declined to 1633, 18 11 IU/mL, 4 6 IU/L one year after BMT, respectively. All the antibody levels were still above cut-off value for positive immunity. Mumps antibody titers were 162 before BMT, declined to 125 significantly from 6 months after BMT, but the antibody level was still above cut-off value.CONCLUSION:
Antibody titers of MMR and hepatitis B decline during the first year after BMT, but the levels are still above cut-off value. Thus, the timing of revaccination should be after the first year post-transplantation. Long-term studies are needed to determine the optimal time for revaccination.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Appointments and Schedules
/
Rubella
/
Bone Marrow
/
Immunoglobulin G
/
Immunoassay
/
Hepatitis B virus
/
Fluorescent Antibody Technique
/
Immunoenzyme Techniques
/
Bone Marrow Transplantation
/
Immunization, Secondary
Type of study:
Practice guideline
Limits:
Humans
Country/Region as subject:
Asia
Language:
Korean
Journal:
Korean Journal of Infectious Diseases
Year:
1998
Type:
Article
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