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Clinical prognostic significance of early lymphocyte recovery after allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia / 中华器官移植杂志
Chinese Journal of Organ Transplantation ; (12): 148-152, 2019.
Article in Chinese | WPRIM | ID: wpr-755913
ABSTRACT
Objective To analyze the clinical significance of early lymphocyte recovery after allogeneic hematopoietic stem cell transplantation (allo-HSCT) in acute myeloid leukemia.Methods The clinical data of 89 patients with acute myeloid leukemia undergoing allo-HSCT were retrospectively analyzed.The absolute lymphocyte count at Day 21 (ALC21) after allo-HSCT was used for representing the recovery rate of lymphocyte.And the effects of ALC21 on disease relapse,overall survival (OS),disease-free survival (DFS) and other parameters were analyzed.Results The recurrent rate of ALC21 ≥0.5 × 109/L group (high ALC21 group) was significantly lower than that of ALC21 <0.5× 109/L group (low ALC21 group) (19.6 % vs 48.5 %,P=0.004).The 2-year OS and DFS of high ALC21 group spiked markedly as compared with low ALC21 group [(74.0 ± 6.0 % vs (46.5±9.5) %,P=0.002],[(70.5 ± 6.2) % vs (44.9±9.3) %,P =0.009] while viral infection rate declined markedly (37.5 % vs 60.6 %,P =0.035).However,non-recurrence mortality (NRM),acute graft-versus-host disease (aGVHD) and chronic graft-versus-host disease (cGVHD) (P =0.556) were not elevated in high ALC21 group as compared with low ALC21 group (P=0.584,P =0.08,P =0.556).Conclusions Early lymphocyte recovery after in acute myeloid leukemia patients has significant early predictive value for recurrence and long-term prognosis after allo-HSCT.

Full text: Available Index: WPRIM (Western Pacific) Type of study: Prognostic study Language: Chinese Journal: Chinese Journal of Organ Transplantation Year: 2019 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Type of study: Prognostic study Language: Chinese Journal: Chinese Journal of Organ Transplantation Year: 2019 Type: Article