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Efficacy of haploidentical allogeneic hematopoietic stem cell transplantation for severe aplastic anemia: a report of 40 cases / 中华器官移植杂志
Chinese Journal of Organ Transplantation ; (12): 153-157, 2019.
Article in Chinese | WPRIM | ID: wpr-755914
ABSTRACT
Objective To explore the efficacy and prognosis of haploidentical allogeneic hematopoietic stem cell transplantation (haplo-HSCT) for severe aplastic anemia (SAA).Methods The clinical data were retrospectively analyzed for 40 SAA cases undergoing haplo-HSCT from September 2013 to February 2018.The conditioning regimen contained cyclophosphamide,fludarabine and antithymocyte globulin with or without busulfan or low-dose total body irradiation.Cyclosporin A,short-term methotrexate and mycophenolate mofetil were dosed for preventing graft versus host disease (GVHD).The median counts of mononuclear cell and CD34+ stem cell were 5.3(2.0~13.5) × 108/kg and 5.6 (1.6 ~ 15.9) × 106/kg respectively.Results Among them,hematopoietic reconstitution was achieved (n =36,90.0 %).The median times for myeloid engraftment and platelet engraftment were 15(10-25) and 17(10~58) days respectively.The incidence of acute graft-versushost disease(aGVHD)was (35.0± 6.8) %.The incidence of chronic GVHD (cGVHD) was (23.0 ±7.4) %.And 28 SAA cases (70.0 %) survived during a median follow-up period of 353(30~1226)days,The cumulative overall survival (OS) was (67.8 ± 7.8) %,the average survival time (883 ± 82)days and transplantation-related death (TRM) within 100 days (10.0 ± 3.1) %.Conclusions Haplo-HSCT is an effective treatment for SAA patients.And a larger number of cases are required for enhancing OS.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Organ Transplantation Year: 2019 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Organ Transplantation Year: 2019 Type: Article