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Matrix Metalloproteinase-1 and Tissue Inhibitor of Metalloproteinase-1 levels in Exudative Pleural Effusions / 결핵및호흡기질환
Tuberculosis and Respiratory Diseases ; : 517-521, 2005.
Article in Korean | WPRIM | ID: wpr-75627
ABSTRACT

BACKGROUND:

The balances of the proteinases and antiproteinases system have been implicated in the pathogenesis of various exudative pleural effusions. The aim of this study was to examine the matrix metalloproteinase-1 (MMP-1) and tissue inhibitor of metalloproteinase-1 (TIMP-1) levels in exudative pleural effusions.

METHODS:

The study included 33 tuberculous effusions, 17 malignant, and 5 transudates. The pleural levels of MMP-1 and TIMP-1 were determined using a commercially available ELISA assay.

RESULTS:

The group of tuberculous effusions showed higher pleural MMP-1 levels than the malignant and transudates. The pleural TIMP-1 levels of the tuberculous and malignant effusions were higher than the transudates.

CONCLUSION:

Elevated pleural MMP-1 and TIMP-1 levels were found in tuberculous effusions.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Peptide Hydrolases / Pleural Effusion / Enzyme-Linked Immunosorbent Assay / Tissue Inhibitor of Metalloproteinase-1 / Matrix Metalloproteinase 1 / Exudates and Transudates Language: Korean Journal: Tuberculosis and Respiratory Diseases Year: 2005 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Peptide Hydrolases / Pleural Effusion / Enzyme-Linked Immunosorbent Assay / Tissue Inhibitor of Metalloproteinase-1 / Matrix Metalloproteinase 1 / Exudates and Transudates Language: Korean Journal: Tuberculosis and Respiratory Diseases Year: 2005 Type: Article