Matrix Metalloproteinase-1 and Tissue Inhibitor of Metalloproteinase-1 levels in Exudative Pleural Effusions / 결핵및호흡기질환
Tuberculosis and Respiratory Diseases
;
: 517-521, 2005.
Article
in Korean
| WPRIM
| ID: wpr-75627
ABSTRACT
BACKGROUND:
The balances of the proteinases and antiproteinases system have been implicated in the pathogenesis of various exudative pleural effusions. The aim of this study was to examine the matrix metalloproteinase-1 (MMP-1) and tissue inhibitor of metalloproteinase-1 (TIMP-1) levels in exudative pleural effusions.METHODS:
The study included 33 tuberculous effusions, 17 malignant, and 5 transudates. The pleural levels of MMP-1 and TIMP-1 were determined using a commercially available ELISA assay.RESULTS:
The group of tuberculous effusions showed higher pleural MMP-1 levels than the malignant and transudates. The pleural TIMP-1 levels of the tuberculous and malignant effusions were higher than the transudates.CONCLUSION:
Elevated pleural MMP-1 and TIMP-1 levels were found in tuberculous effusions.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Peptide Hydrolases
/
Pleural Effusion
/
Enzyme-Linked Immunosorbent Assay
/
Tissue Inhibitor of Metalloproteinase-1
/
Matrix Metalloproteinase 1
/
Exudates and Transudates
Language:
Korean
Journal:
Tuberculosis and Respiratory Diseases
Year:
2005
Type:
Article
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