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The role of intercellular transfer of P-glycoprotein in tumor drug resistance / 肿瘤研究与临床
Cancer Research and Clinic ; (6): 351-354, 2019.
Article in Chinese | WPRIM | ID: wpr-756755
ABSTRACT
Multidrug resistance is a major cause of clinical failure of tumor chemotherapy, study on the mechanisms of tumor multidrug resistance has been becoming a fascinating area in the field of tumor chemotherapy. The tumor multidrug resistance is generally considered to be due to the gene mutation, amplification or epigenetic changes that affect the uptake , metabolism or excretion of tumor drugs . P-glycoprotein is a transmembrane glycoprotein encoded by multidrug resistance gene MDR1, which leads to the principal contributor to tumor multidrug resistance. Research suggests that P-glycoprotein can metastasize through the tumor cells, thereby affecting tumor resistance. This article reviews the role of intercellular transfer of P-glycoprotein in tumor drug resistance.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Cancer Research and Clinic Year: 2019 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Cancer Research and Clinic Year: 2019 Type: Article