Effects of Pranoprofen on the retinal structure and serum levels of VEGF in patients with cataract surgery / 国际眼科杂志(Guoji Yanke Zazhi)

ABSTRACT

@#AIM: To evaluate the effects of pranoprofen on the retinal structure and serum levels of vascular endothelial growth factor(VEGF)in patients with cataract surgery.<p>METHODS: One hundred and seventy two cataract patients(200 eyes)were enrolled in this study. All the patients were randomly divided into observation group and control group. The patients of observation group were treated with pranoprofen combined with normal post-operative therapy for 1mo. We set 4 points(1d, 7d, 15d and 30d after surgery)to dynamically analyze the fluctuation of inflammation score, central macular retinal thickness(CMT), macular foveola retinal thickness(MFRT), and the light receptor inner segment and outer segment layer(IS/OS). We set two points(before and 30d after surgery)to dynamically observe the alteration of superoxide dismutase(SOD), malondialdehyde(MDA)and VEGF.<p>RESULTS: The levels of inflammation index in control group were higher than those in observation group 7d, 15d and 30d after surgery, respectively(<i>P</i><0.001). The levels of CMT in control group were higher than those in observation group 15d and 30d after surgery, respectively(<i>P</i><0.001). The levels of IS/OS in control group were lower than those in observation group 7d, 15d and 30d after surgery, respectively(<i>P</i><0.001). Both of two groups expressed a markedly increasing of SOD levels(<i>P</i><0.001)and decreasing of MDA and VEGF levels(<i>P</i><0.001)30d after surgery compared with those before surgery. The levels of SOD in control group were lower than those in observation group(<i>P</i><0.001), whereas the contents of MDA and VEGF in control group were higher than those in observation group(<i>P</i><0.001)30d after surgery.<p>CONCLUSION: Pranoprofen considerably relieve levels of inflammation injury and down-regulate circulating levels of VEGF, which contributes its promotion in the recovery of retinal structure after surgery.