Mammalian mitochondrial RNAs are degraded in the mitochondrial intermembrane space by RNASET2
Protein & Cell
;
(12): 735-749, 2017.
Article
in English
| WPRIM
| ID: wpr-756951
ABSTRACT
Mammalian mitochondrial genome encodes a small set of tRNAs, rRNAs, and mRNAs. The RNA synthesis process has been well characterized. How the RNAs are degraded, however, is poorly understood. It was long assumed that the degradation happens in the matrix where transcription and translation machineries reside. Here we show that contrary to the assumption, mammalian mitochondrial RNA degradation occurs in the mitochondrial intermembrane space (IMS) and the IMS-localized RNASET2 is the enzyme that degrades the RNAs. This provides a new paradigm for understanding mitochondrial RNA metabolism and transport.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Ribonucleases
/
RNA
/
Cell Line
/
Chemistry
/
RNA Stability
/
Protein Transport
/
Tumor Suppressor Proteins
/
Mitochondrial Membranes
/
RNA, Mitochondrial
/
Metabolism
Limits:
Humans
Language:
English
Journal:
Protein & Cell
Year:
2017
Type:
Article
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