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The SWI/SNF chromatin-remodeling factors BAF60a, b, and c in nutrient signaling and metabolic control
Protein & Cell ; (12): 207-215, 2018.
Article in English | WPRIM | ID: wpr-756955
ABSTRACT
Metabolic syndrome has become a global epidemic that adversely affects human health. Both genetic and environmental factors contribute to the pathogenesis of metabolic disorders; however, the mechanisms that integrate these cues to regulate metabolic physiology and the development of metabolic disorders remain incompletely defined. Emerging evidence suggests that SWI/SNF chromatin-remodeling complexes are critical for directing metabolic reprogramming and adaptation in response to nutritional and other physiological signals. The ATP-dependent SWI/SNF chromatin-remodeling complexes comprise up to 11 subunits, among which the BAF60 subunit serves as a key link between the core complexes and specific transcriptional factors. The BAF60 subunit has three members, BAF60a, b, and c. The distinct tissue distribution patterns and regulatory mechanisms of BAF60 proteins confer each isoform with specialized functions in different metabolic cell types. In this review, we summarize the emerging roles and mechanisms of BAF60 proteins in the regulation of nutrient sensing and energy metabolism under physiological and disease conditions.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Signal Transduction / Nutrients / Disease / Chromatin Assembly and Disassembly / DNA-Binding Proteins / Metabolism Type of study: Prognostic study Limits: Humans Language: English Journal: Protein & Cell Year: 2018 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Signal Transduction / Nutrients / Disease / Chromatin Assembly and Disassembly / DNA-Binding Proteins / Metabolism Type of study: Prognostic study Limits: Humans Language: English Journal: Protein & Cell Year: 2018 Type: Article