Potent and conditional redirected T cell killing of tumor cells using Half DVD-Ig
Protein & Cell
;
(12): 121-129, 2018.
Article
in English
| WPRIM
| ID: wpr-756967
ABSTRACT
Novel biologics that redirect cytotoxic T lymphocytes (CTLs) to kill tumor cells bearing a tumor associated antigen hold great promise in the clinic. However, the ability to safely and potently target CD3 on CTL toward tumor associated antigens (TAA) expressed on tumor cells remains a challenge of both technology and biology. Herein we describe the use of a Half DVD-Ig format that can redirect CTL to kill tumor cells. Notably, Half DVD-Ig molecules that are monovalent for each specificity demonstrated reduced non-specific CTL activation and conditional CTL activation upon binding to TAA compared to intact tetravalent DVD-Ig molecules that are bivalent for each specificity, while maintaining good drug like properties and appropriate PK properties.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Pharmacokinetics
/
Lymphocyte Activation
/
T-Lymphocytes, Cytotoxic
/
Mice, SCID
/
Rats, Sprague-Dawley
/
CD3 Complex
/
Antibodies, Bispecific
/
Cytotoxicity, Immunologic
/
Cell Line, Tumor
Limits:
Animals
/
Female
/
Humans
Language:
English
Journal:
Protein & Cell
Year:
2018
Type:
Article
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