The role of galectin-4 in physiology and diseases
Protein & Cell
;
(12): 314-324, 2016.
Article
in English
| WPRIM
| ID: wpr-757132
ABSTRACT
Galectin-4, a tandem repeat member of the β-galactoside-binding proteins, possesses two carbohydrate-recognition domains (CRD) in a single peptide chain. This lectin is mostly expressed in epithelial cells of the intestinal tract and secreted to the extracellular. The two domains have 40% similarity in amino acid sequence, but distinctly binding to various ligands. Just because the two domains bind to different ligands simultaneously, galectin-4 can be a crosslinker and crucial regulator in a large number of biological processes. Recent evidence shows that galectin-4 plays an important role in lipid raft stabilization, protein apical trafficking, cell adhesion, wound healing, intestinal inflammation, tumor progression, etc. This article reviews the physiological and pathological features of galectin-4 and its important role in such processes.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Axons
/
Wound Healing
/
Blood
/
Inflammatory Bowel Diseases
/
Membrane Microdomains
/
Galectin 4
/
Endocytosis
/
Genetics
/
Metabolism
Limits:
Animals
/
Humans
Language:
English
Journal:
Protein & Cell
Year:
2016
Type:
Article
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