Onco-miR-24 regulates cell growth and apoptosis by targeting BCL2L11 in gastric cancer
Protein & Cell
; (12): 141-151, 2016.
Article
in En
| WPRIM
| ID: wpr-757156
Responsible library:
WPRO
ABSTRACT
Gastric cancer is one of the most common malignancies worldwide; however, the molecular mechanism in tumorigenesis still needs exploration. BCL2L11 belongs to the BCL-2 family, and acts as a central regulator of the intrinsic apoptotic cascade and mediates cell apoptosis. Although miRNAs have been reported to be involved in each stage of cancer development, the role of miR-24 in GC has not been reported yet. In the present study, miR-24 was found to be up-regulated while the expression of BCL2L11 was inhibited in tumor tissues of GC. Studies from both in vitro and in vivo shown that miR-24 regulates BCL2L11 expression by directly binding with 3'UTR of mRNA, thus promoting cell growth, migration while inhibiting cell apoptosis. Therefore, miR-24 is a novel onco-miRNA that can be potential drug targets for future clinical use.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Pathology
/
Stomach Neoplasms
/
Base Sequence
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Down-Regulation
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Cell Movement
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Proto-Oncogene Proteins
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Apoptosis
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Gene Silencing
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MicroRNAs
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Cell Line, Tumor
Limits:
Animals
Language:
En
Journal:
Protein & Cell
Year:
2016
Type:
Article