Thermodynamics of ABC transporters
Protein & Cell
;
(12): 17-27, 2016.
Article
in English
| WPRIM
| ID: wpr-757179
ABSTRACT
ABC transporters form the largest of all transporter families, and their structural study has made tremendous progress over recent years. However, despite such advances, the precise mechanisms that determine the energy-coupling between ATP hydrolysis and the conformational changes following substrate binding remain to be elucidated. Here, we present our thermodynamic analysis for both ABC importers and exporters, and introduce the two new concepts of differential-binding energy and elastic conformational energy into the discussion. We hope that the structural analysis of ABC transporters will henceforth take thermodynamic aspects of transport mechanisms into account as well.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Thermodynamics
/
Adenosine Triphosphate
/
ATP-Binding Cassette Transporters
/
Metabolism
/
Models, Theoretical
Limits:
Animals
/
Humans
Language:
English
Journal:
Protein & Cell
Year:
2016
Type:
Article
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