Phenotypic Tfh development promoted by CXCR5-controlled re-localization and IL-6 from radiation-resistant cells
Protein & Cell
;
(12): 825-832, 2015.
Article
in English
| WPRIM
| ID: wpr-757183
ABSTRACT
How follicular T-helper (Tfh) cells develop is incompletely understood. We find that, upon antigen exposure in vivo, both naïve and antigen-experienced T cells sequentially upregulate CXCR5 and Bcl6 within the first 24 h, relocate to the T-B border, and give rise to phenotypic Bcl6(+)CXCR5(+) Tfh cells before the first cell division. CXCR5 upregulation is more dependent on ICOS costimulation than that of Bcl6, and early Bcl6 induction requires T-cell expression of CXCR5 and, presumably, relocation toward the follicle. This early and rapid upregulation of CXCR5 and Bcl6 depends on IL-6 produced by radiation-resistant cells. These results suggest that a Bcl6(hi)CXCR5(hi) phenotype does not automatically define a Tfh lineage but might reflect a state of antigen exposure and non-commitment to terminal effector fates and that niches in the T-B border and/or the follicle are important for optimal Bcl6 induction and maintenance.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Cell Differentiation
/
Interleukin-6
/
T-Lymphocytes, Helper-Inducer
/
CD40 Ligand
/
DNA-Binding Proteins
/
Proto-Oncogene Proteins c-bcl-6
/
Receptors, CXCR5
/
Inducible T-Cell Co-Stimulator Protein
/
Metabolism
Limits:
Animals
Language:
English
Journal:
Protein & Cell
Year:
2015
Type:
Article
Similar
MEDLINE
...
LILACS
LIS