Atg7 in development and disease: panacea or Pandora's Box?
Protein & Cell
;
(12): 722-734, 2015.
Article
in English
| WPRIM
| ID: wpr-757184
ABSTRACT
Macroautophagy is an evolutionarily conserved intracellular degradation system used by life ranging from yeasts to mammals. The core autophagic machinery is composed of ATG (autophagy-related) protein constituents. One particular member of the ATG protein family, Atg7, has been the focus of recent research. Atg7 acts as an E1-like activating enzyme facilitating both microtubule-associated protein light chain 3 (LC3)-phosphatidylethanolamine and ATG12 conjugation. Thus, Atg7 stands at the hub of these two ubiquitin-like systems involving LC3 and Atg12 in autophagic vesicle expansion. In this review, I focus on the pleiotropic function of Atg7 in development, maintenance of health, and alternations of such control in disease.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Organ Specificity
/
Species Specificity
/
Disease
/
Ubiquitin-Activating Enzymes
/
Growth and Development
/
Metabolism
Limits:
Animals
/
Humans
Language:
English
Journal:
Protein & Cell
Year:
2015
Type:
Article
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