Eliminate mitochondrial diseases by gene editing in germ-line cells and embryos
Protein & Cell
;
(12): 472-475, 2015.
Article
in English
| WPRIM
| ID: wpr-757219
ABSTRACT
Nuclease-based gene editing technologies have opened up opportunities for correcting human genetic diseases. For the first time, scientists achieved targeted gene editing of mitochondrial DNA in mouse oocytes fused with patient cells. This fascinating progression may encourage the development of novel therapy for human maternally inherent mitochondrial diseases.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Therapeutics
/
DNA, Mitochondrial
/
Genome
/
RNA Editing
/
Mitochondrial Diseases
/
Embryo, Mammalian
/
Genetics
/
Germ Cells
/
Metabolism
Limits:
Animals
/
Humans
Language:
English
Journal:
Protein & Cell
Year:
2015
Type:
Article
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