Suppression of GSK3β by ERK mediates lipopolysaccharide induced cell migration in macrophage through β-catenin signaling
Protein & Cell
;
(12): 762-768, 2012.
Article
in English
| WPRIM
| ID: wpr-757223
ABSTRACT
We investigate the role of β-catenin signaling in the response of macrophage to lipopolysaccharide (LPS) using RAW264.7 cells. LPS rapidly stimulated cytosolic β-catenin accumulation. β-catenin-mediated transcription was showed to be required for LPS induced gene expression and cell migration. Mechanically, ERK activation-primed GSK3β inactivation by Akt was demonstrated to mediate the LPS induced β-catenin accumulation. Overall, our findings suggest that suppression of GSK3β by ERK stimulates β-catenin signaling therefore contributes to LPS induced cell migration in macrophage activation.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Transcription, Genetic
/
Signal Transduction
/
Gene Expression Regulation, Enzymologic
/
Cell Line
/
Cell Movement
/
Lipopolysaccharides
/
Matrix Metalloproteinase 9
/
Cell Biology
/
Glycogen Synthase Kinase 3
Limits:
Animals
Language:
English
Journal:
Protein & Cell
Year:
2012
Type:
Article
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