Bulk-like endocytosis plays an important role in the recycling of insulin granules in pancreatic beta cells
Protein & Cell
;
(12): 618-626, 2012.
Article
in English
| WPRIM
| ID: wpr-757249
ABSTRACT
Although bulk endocytosis has been found in a number of neuronal and endocrine cells, the molecular mechanism and physiological function of bulk endocytosis remain elusive. In pancreatic beta cells, we have observed bulk-like endocytosis evoked both by flash photolysis and trains of depolarization. Bulk-like endocytosis is a clathrin-independent process that is facilitated by enhanced extracellular Ca(2+) entry and suppressed by the inhibition of dynamin function. Moreover, defects in bulk-like endocytosis are accompanied by hyperinsulinemia in primary beta cells dissociated from diabetic KKAy mice, which suggests that bulk-like endocytosis plays an important role in maintaining the exo-endocytosis balance and beta cell secretory capability.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Photolysis
/
Physiology
/
Calcium
/
Patch-Clamp Techniques
/
Cytoplasmic Granules
/
Electric Capacitance
/
Dynamins
/
Diabetes Mellitus
/
Disease Models, Animal
Type of study:
Prognostic study
Limits:
Animals
Language:
English
Journal:
Protein & Cell
Year:
2012
Type:
Article
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