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Bulk-like endocytosis plays an important role in the recycling of insulin granules in pancreatic beta cells
Protein & Cell ; (12): 618-626, 2012.
Article in English | WPRIM | ID: wpr-757249
ABSTRACT
Although bulk endocytosis has been found in a number of neuronal and endocrine cells, the molecular mechanism and physiological function of bulk endocytosis remain elusive. In pancreatic beta cells, we have observed bulk-like endocytosis evoked both by flash photolysis and trains of depolarization. Bulk-like endocytosis is a clathrin-independent process that is facilitated by enhanced extracellular Ca(2+) entry and suppressed by the inhibition of dynamin function. Moreover, defects in bulk-like endocytosis are accompanied by hyperinsulinemia in primary beta cells dissociated from diabetic KKAy mice, which suggests that bulk-like endocytosis plays an important role in maintaining the exo-endocytosis balance and beta cell secretory capability.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Photolysis / Physiology / Calcium / Patch-Clamp Techniques / Cytoplasmic Granules / Electric Capacitance / Dynamins / Diabetes Mellitus / Disease Models, Animal Type of study: Prognostic study Limits: Animals Language: English Journal: Protein & Cell Year: 2012 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Photolysis / Physiology / Calcium / Patch-Clamp Techniques / Cytoplasmic Granules / Electric Capacitance / Dynamins / Diabetes Mellitus / Disease Models, Animal Type of study: Prognostic study Limits: Animals Language: English Journal: Protein & Cell Year: 2012 Type: Article