The potential link between PML NBs and ICP0 in regulating lytic and latent infection of HSV-1
Protein & Cell
;
(12): 372-382, 2012.
Article
in English
| WPRIM
| ID: wpr-757269
ABSTRACT
Herpes simplex virus type 1 (HSV-1) is a common human pathogen causing cold sores and even more serious diseases. It can establish a latent stage in sensory ganglia after primary epithelial infections, and reactivate in response to stress or sunlight. Previous studies have demonstrated that viral immediate-early protein ICP0 plays a key role in regulating the balance between lytic and latent infection. Recently, It has been determined that promyelocytic leukemia (PML) nuclear bodies (NBs), small nuclear sub-structures, contribute to the repression of HSV-1 infection in the absence of functional ICP0. In this review, we discuss the fundamentals of the interaction between ICP0 and PML NBs, suggesting a potential link between PML NBs and ICP0 in regulating lytic and latent infection of HSV-1.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Virology
/
Leukemia, Promyelocytic, Acute
/
Virus Latency
/
Immediate-Early Proteins
/
Herpesvirus 1, Human
/
Intranuclear Inclusion Bodies
/
Ubiquitin-Protein Ligases
/
Genetics
/
Herpes Simplex
Limits:
Humans
Language:
English
Journal:
Protein & Cell
Year:
2012
Type:
Article
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