Hippo pathway in intestinal homeostasis and tumorigenesis
Protein & Cell
;
(12): 305-310, 2012.
Article
in English
| WPRIM
| ID: wpr-757277
ABSTRACT
The Hippo pathway plays a crucial role in controlling organ size by inhibiting cell proliferation and promoting cell death. Recent findings implicate that this pathway is involved in the process of intestinal regeneration and tumorigenesis. Here we summarize current studies for the function of the Hippo signaling pathway in intestinal homeostasis, regeneration and tumorigenesis, and the crosstalk between the Hippo signaling pathway and other major signaling pathways, i.e. Wnt, Notch and Jak/Stat signaling pathways in intestinal compartment.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Regeneration
/
Nuclear Proteins
/
Signal Transduction
/
Cell Transformation, Neoplastic
/
Protein Serine-Threonine Kinases
/
Drosophila Proteins
/
Intracellular Signaling Peptides and Proteins
/
Drosophila
/
Homeostasis
/
Intestinal Mucosa
Limits:
Animals
Language:
English
Journal:
Protein & Cell
Year:
2012
Type:
Article
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