Multifaceted functions of Siva-1: more than an Indian God of Destruction
Protein & Cell
;
(12): 117-122, 2012.
Article
in English
| WPRIM
| ID: wpr-757290
ABSTRACT
Siva-1, as a p53-inducible gene, has been shown to induce extensive apoptosis in a number of different cell lines. Recent evidence suggests that Siva-1 functions as a part of the auto-regulatory feedback loop that restrains p53 through facilitating Mdm2-mediated p53 degradation. Also, Siva-1 plays an important role in suppressing tumor metastasis. Here we review the current understanding of Siva-1-mediated apoptotic signaling pathway. We also add comments on the p53-Siva-1 feedback loop, the novel function of Siva-1 in suppressing tumor metastasis, and their potential implications.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Signal Transduction
/
Tumor Suppressor Protein p53
/
Apoptosis
/
Feedback, Physiological
/
Proto-Oncogene Proteins c-mdm2
/
Apoptosis Regulatory Proteins
/
Metabolism
/
Models, Biological
/
Neoplasm Metastasis
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Protein & Cell
Year:
2012
Type:
Article
Similar
MEDLINE
...
LILACS
LIS