Cocktail of chemical compounds robustly promoting cell reprogramming protects liver against acute injury
Protein & Cell
;
(12): 273-283, 2017.
Article
in English
| WPRIM
| ID: wpr-757321
ABSTRACT
Tissue damage induces cells into reprogramming-like cellular state, which contributes to tissue regeneration. However, whether factors promoting the cell reprogramming favor tissue regeneration remains elusive. Here we identified combination of small chemical compounds including drug cocktails robustly promoting in vitro cell reprogramming. We then administrated the drug cocktails to mice with acute liver injuries induced by partial hepatectomy or toxic treatment. Our results demonstrated that the drug cocktails which promoted cell reprogramming in vitro improved liver regeneration and hepatic function in vivo after acute injuries. The underlying mechanism could be that expression of pluripotent genes activated after injury is further upregulated by drug cocktails. Thus our study offers proof-of-concept evidence that cocktail of clinical compounds improving cell reprogramming favors tissue recovery after acute damages, which is an attractive strategy for regenerative purpose.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Cell Biology
/
Cellular Reprogramming
/
Induced Pluripotent Stem Cells
/
Cellular Reprogramming Techniques
/
Metabolism
/
Methods
Type of study:
Prognostic study
Limits:
Animals
Language:
English
Journal:
Protein & Cell
Year:
2017
Type:
Article
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