miR-27b inhibits gastric cancer metastasis by targeting NR2F2
Protein & Cell
;
(12): 114-122, 2017.
Article
in English
| WPRIM
| ID: wpr-757355
ABSTRACT
Increasing attention is focused on the down-regulation of miRNAs in cancer process. Nuclear receptor subfamily 2 (NR2F2, also known as COUP-TFII) is involved in the development of many types of cancers, but its role in gastric cancer remains elusive. In this experiment, oncomine and Kaplan-meier database revealed that NR2F2 was up-regulated in gastric cancer and that the high NR2F2 expression contributed to poor survival. MicroRNA-27b was targeted and down-regulated by NR2F2 in human gastric cancer tissues and cells. The ectopic expression of miR-27b inhibited gastric cancer cell proliferation and tumor growth in vitro and in vivo. Assays suggested that the overexpression of miR-27b could promote MGC-803 cells' migration and invasion and retard their metastasis to the liver. In addition, down-regulation of miR-27b enhanced GES-1 cells' proliferation and metastasis in vitro. These findings reveal that miR-27b is a tumor suppressor in gastric cancer and a biomarker for improving patients' survival.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Stomach Neoplasms
/
RNA, Neoplasm
/
Biomarkers, Tumor
/
Genes, Tumor Suppressor
/
MicroRNAs
/
Cell Line, Tumor
/
COUP Transcription Factor II
/
Heterografts
/
Genetics
Limits:
Animals
/
Female
/
Humans
/
Male
Language:
English
Journal:
Protein & Cell
Year:
2017
Type:
Article
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