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Evolution from genetics to phenotype: reinterpretation of NSCLC plasticity, heterogeneity, and drug resistance
Protein & Cell ; (12): 178-190, 2017.
Article in English | WPRIM | ID: wpr-757374
ABSTRACT
Lung cancer is the leading cause of cancer-related deaths worldwide. Targeted therapy is beneficial in most cases, but the development of drug resistance stands as an obstacle to good prognosis. Multiple mechanisms were explored such as genetic alterations, activation of bypass signaling, and phenotypic transition. These intrinsic and/or extrinsic dynamic regulations facilitate tumor cell survival in meeting the demands of signaling under different stimulus. This review introduces lung cancer plasticity and heterogeneity and their correlation with drug resistance. While cancer plasticity and heterogeneity play an essential role in the development of drug resistance, the manipulation of them may bring some inspirations to cancer prognosis and treatment. That is to say, lung cancer plasticity and heterogeneity present us with not only challenges but also opportunities.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Carcinoma, Non-Small-Cell Lung / Drug Resistance, Neoplasm / Genetics / Lung Neoplasms / Metabolism Limits: Humans Language: English Journal: Protein & Cell Year: 2017 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Carcinoma, Non-Small-Cell Lung / Drug Resistance, Neoplasm / Genetics / Lung Neoplasms / Metabolism Limits: Humans Language: English Journal: Protein & Cell Year: 2017 Type: Article