RNF152, a novel lysosome localized E3 ligase with pro-apoptotic activities
Protein & Cell
;
(12): 656-663, 2010.
Article
in English
| WPRIM
| ID: wpr-757423
ABSTRACT
RING finger protein 152 (RNF152) is a novel RING finger protein and has not been well characterized. We report here that RNF152 is a canonical RING finger protein and has E3 ligase activity. It is polyubiqitinated partly through Lys-48-linked ubiquitin chains in vivo and this phenomenon is dependent on its RING finger domain and transmembrane domain. RNF152 is localized in lysosomes and co-localized with LAMP3, a lysosome marker. Moreover, over-expression of RNF152 in Hela cells induces apoptosis. These results suggest that RNF152 is a lysosome localized E3 ligase with pro-apoptotic activities. It is the first E3 ligase identified so far that is involved in lysosome-related apoptosis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phylogeny
/
Molecular Sequence Data
/
HeLa Cells
/
Sequence Alignment
/
Amino Acid Sequence
/
Apoptosis
/
Ubiquitin-Protein Ligases
/
Proteasome Endopeptidase Complex
/
RING Finger Domains
/
Ubiquitination
Limits:
Humans
Language:
English
Journal:
Protein & Cell
Year:
2010
Type:
Article
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