Engineering of a genome-reduced host: practical application of synthetic biology in the overproduction of desired secondary metabolites
Protein & Cell
;
(12): 621-626, 2010.
Article
in English
| WPRIM
| ID: wpr-757426
ABSTRACT
Synthetic biology aims to design and build new biological systems with desirable properties, providing the foundation for the biosynthesis of secondary metabolites. The most prominent representation of synthetic biology has been used in microbial engineering by recombinant DNA technology. However, there are advantages of using a deleted host, and therefore an increasing number of biotechnology studies follow similar strategies to dissect cellular networks and construct genome-reduced microbes. This review will give an overview of the strategies used for constructing and engineering reduced-genome factories by synthetic biology to improve production of secondary metabolites.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Sesquiterpenes
/
Streptomyces
/
Streptomycin
/
Genetic Engineering
/
Cephamycins
/
Genome
/
Gene Deletion
/
Epoxy Compounds
/
Escherichia coli
/
Biosynthetic Pathways
Language:
English
Journal:
Protein & Cell
Year:
2010
Type:
Article
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